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It has been demonstrated that histone modi¼cations are implicated in the regulation of
transcription. Recent studies have revealed complex links between H2B ubiquitination and the
control of transcription. Some studies suggest that H2B ubiquitination plays a role in
transcriptional silencing whereas others suggest a role in transcriptional initiation and
elongation. This antibody was raised against a branched peptide corresponding to the
conjugation site of ubiquitin on human histone H2B.
