Clone 10.1 (See other available formats) Regulatory Status RUO Workshop VI MA36 Other Names FcγRI, FcR I Isotype Mouse IgG1, κ Antigen Details Structure Ig superfamily, type I glycoprotein, 72 kD Distribution Monocytes, macrophages, dendritic cells, activated granulocytes Function Phagocytosis, ADCC Ligand/Receptor IgG receptor Cell Type Dendritic cells, Granulocytes, Macrophages, Monocytes Biology Area Immunology, Innate Immunity Molecular Family CD Molecules, Fc Receptors Antigen References 1. Hulett M, et al. 1994. Adv. Immunol. 57:1. 2. van de Winkel J, et al. 1993. Immunol. Today 14:215. Gene ID 2209 CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcR I. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC).