Clone 104 (See other available formats) Regulatory Status RUO Other Names Ly-5.2, LCA Isotype Mouse (SJL) IgG2a, κ Antigen Details Structure Protein tyrosine phosphatase (PTP) family, 180-240 kD Distribution All hematopoietic cells except mature erythrocytes and platelets of the CD45.2 strain of mice Function Phosphatase, T and B cell activation Ligand/Receptor Galectin-1, CD2, CD3, CD4 Biology Area Cell Biology, Immunology, Inhibitory Molecules, Innate Immunity, Neuroscience, Neuroscience Cell Markers Molecular Family CD Molecules Antigen References 1. Suzuki K, et al. 2000. Immunity 13:691. Gene ID 19264 CD45.2 is an alloantigen of CD45, expressed by Ly5.2 bearing mouse strains (e.g., A, AKR, BALB/c, CBA/Ca, CBA/J, C3H/He, C57BL, C57BR, C57L, C58, DBA/1, DBA/2, NZB, SWR, 129). CD45, a member of the protein tyrosine phosphatase (PTP) family, is a 180-240 kD glycoprotein expressed on all hematopoietic cells except mature erythrocytes and platelets. There are multiple isoforms in the mouse that play key roles in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation states of the cell as well as specific cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.