Clone 104D2 (See other available formats) Regulatory Status RUO Other Names Stem cell factor receptor, c-kit, mast cell growth factor receptor, steel factor receptor Isotype Mouse IgG1, κ Antigen Details Structure Growth factor receptor with tyrosine kinase activity, subclass III, approximately 145 kD Distribution Pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, acute myeloid leukemic cells (AML) Function Growth factor receptor for stem cell factor. Induces proliferation and survival of primitive hematopoietic progenitors. Potent inducer of proliferation in erythroid-committed progenitor cells. Defects in CD117 have been linked to severe anemia and a decreased number of hematopoietic progenitor cells. Ligand/Receptor c-Kit ligand Modification Multiple phosphorylation sites Cell Type Embryonic Stem Cells, Hematopoietic stem and progenitors, Leukemia, Mast cells, Mesenchymal Stem Cells Biology Area Immunology, Stem Cells Molecular Family CD Molecules Antigen References 1. Giebel LB, et al. 1992. Oncogene 7:2207. 2. Furitsu T, et al. 1993. J. Clin. Invest. 92:1736. Gene ID 3815 CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells.