Clone 108-17 (See other available formats) Regulatory Status RUO Other Names TNFRSF18, Activation-inducible TNFR, AITR, Glucocorticoid-inducible TNFR Isotype Mouse IgG2a, κ Antigen Details Structure TNFR superfamily, 234-amino acid type I transmembrane protein, 25 kD. Distribution Activated lymphocytes. Function Interacts with TRAF's 1-3, but not TRAF 5 or 6, mediates NF-κB activation through the TRAF2/NIK pathway. Ligand/Receptor GITRL Cell Type Lymphocytes, Tregs Biology Area Costimulatory Molecules, Immunology Molecular Family CD Molecules Antigen References 1. van der Werf N, et al. 2011. J. Immunol. 187:1411. 2. Shimizu J, et al. 2002. Nat. Immunol. 3:135. 3. McHugh RS, et al. 2002. Immunity 16:311. 4. Kwon B, et al. 1999. J. Biol. Chem. 274:6056. Gene ID 8784 GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets.