Clone 10D1-J16 (See other available formats) Regulatory Status RUO Other Names Chemokine (C-X-C motif) receptor 7, RDC1, CMKOR1, GPR159, ACKR3 Isotype Mouse IgG2a, κ Antigen Details Structure G Protein-Coupled Receptor super family Distribution Monocytes, B cells, T cells, and mature dendritic cells. Function Regulates trafficking and activation of leukocytes. Ligand/Receptor CXCL12/SDF-1 and CXCL11/I-TAC. Cell Type Monocytes, B cells, T cells, Dendritic cells Biology Area Cell Biology, Immunology, Signal Transduction Molecular Family CD Molecules, Cytokine/Chemokine Receptors, GPCR Antigen References 1. Torossian F, et al. 2014. Blood 123:191.2. Walentowicz-Sadlecka M, et al. 2014. PLoS One 1:e84629.3. Yates TJ, et al. 2013. Cancer 119:61.4. Burns JM, et al. 2006. J. Exp. Med. 203:2201.5. Infantino S, et al. 2006. J. Immunol. 176:2197. Gene ID 57007 CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with a high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. The binding of a ligand to CXCR7 induces proliferation and migration of immature neurons, glia, and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells, and mature dendritic cells. Surface expression of CXCR7 has been also reported in tumor cells, activated endothelial cells, and fetal liver cells.