Clone 10E2 (See other available formats) Regulatory Status RUO Other Names CLEC4K Isotype Mouse IgG1, κ Antigen Details Structure 40 kD glycoprotein Distribution Langerhans cells, dermal CD103-positive dendritic cells, and splenic CD8-positive dendritic cells Function Binding and processing antigen; capturing, internalizing and degrading HIV Ligand/Receptor Antigen containing mannose, N-acetyl glucosamine, and fucose Cell Type Dendritic cells, Langerhans cells Biology Area Immunology, Innate Immunity Molecular Family CD Molecules Antigen References 1. Valladeau J, et al. 2000. Immunity 12:71. 2. Mc Dermott R, et al. 2002. Mol. Biol. Cell. 13:317. 3. Mizumoto N, et al. 2004. J. Clin. Invest. 113:701. 4. Witte LD, et al. 2007. Nat. Med. 13:367. Gene ID 50489 CD207, also known as Langerin, is a 40 kD type II transmemberane cell glycoprotein which belongs to C-type lectin with mannose binding specificity. It is predominantly expressed on Langerhans cells and induces the formation of Birbeck granules, the Langerhans cell hallmark organelle. It is also found on several other subtypes of dendritic cells, such as dermal CD103-positive dendritic cells and splenic CD8-positive dendritic cells. Langerin is generally thought to be involved in antigen processing. Recently, it has been found that HIV captured by Langerin was internalized into Birbeck granule and degraded, which results in inhibition of HIV-1 infection and subsequent transmission.