Clone 10E5 (See other available formats) Regulatory Status RUO Other Names DNAM-1, PTA1 (platelet and T cell activation antigen 1), TLISA1, LFA-1 associated Molecule PTA-1 Isotype Rat IgG2b, κ Antigen Details Structure 65 kd glycoprotein of a member of Ig-superfamily containing 2 immunologlobulin-like domains. Distribution Expressed on majority of CD4+ and CD8+ T cells, NK cells, monocytes/macrophages and a subset of B cells and thymocytes. Reported to be specifically expressed on the surface of Th1 cells, but downregulated in Th2 cells. Function Mediates cellular adhesion, involved in LFA-1 costimulatory signal for T cell differentiation and proliferation Ligand/Receptor CD112 and CD155 Cell Type B cells, Macrophages, Monocytes, NK cells, T cells, Th1 Biology Area Immunology Molecular Family Adhesion Molecules, CD Molecules Antigen References 1.Tahara Hanaoka S, et al. 2006. Blood 107:1491 2. Shibuya K, et al. 2003. J. Exp. Med. 198:1829 Gene ID 225825 CD226 (DNAM-1) is constitutively expressed on native CD8+ cells and on CD4+ T cells, macrophages and NK cells.This antibody (10E5) was reported to bind about 40% of inactivated CD4+ cells and binds only to differentiated Th1 cells, but not to Th2 or Th0 cells.It is also reported to suppress antigen-specific T cell expansion and EAE (experimental allergic encephalitis) mediated by Th1 cells.