Clone 10F.9G2 (See other available formats) Regulatory Status RUO Other Names B7-H1, PD-L1 Isotype Rat IgG2b, κ Antigen Details Structure 40 kD type I transmembrane protein member of B7 family within the immunoglobulin receptor superfamily Distribution T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes Ligand/Receptor PD-1 (PDCD1) Cell Type B cells, Dendritic cells, Endothelial cells, Monocytes, NK cells, T cells Biology Area Cancer Biomarkers, Costimulatory Molecules, Immunology Molecular Family Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors Antigen References 1. Sharpe A, et al. 2007. Nat. Immunol. 8:239. 2. Dong H, et al. 1999. Nat. Med. 5:1365. 3. Freeman G, et al. 2000. J. Exp. Med. 192:1027. Gene ID 60533 CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.