Clone 11-5/CRTAM (See other available formats) Regulatory Status RUO Other Names Class I-restricted T cell-associated molecule Isotype Rat IgG2a, κ Antigen Details Structure 75 kD homodimer, nectin family, Ig superfamily Distribution Activated NK cells and activated CD8-positive T cells Function Cell adhesion, migration Ligand/Receptor Nectin-like molecule 2 Cell Type NK cells, T cells Biology Area Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Signal Transduction Molecular Family Adhesion Molecules, CD Molecules Antigen References 1. Takeuchi A, et al. 2009. J. Immunol. 183:4220. 2. Yeh JH, et al. 2008. Cell 132:846. 3. Arase N. 2005. Int. Immunol. 17:1227. 4. Boles KS, et al. 2005. Blood 106:779. 5. Galibert L, et al. 2005 J. Biol. Chem. 280:21955. 6. Kennedy J, et al. 2000 J. Leukoc. Biol. 67:725. Gene ID 54698 Class-I MHC-restricted T-cell associated molecule (CRTAM), designated as CD355, is an Ig domain like type I transmembrane receptor, which belongs to the nectin family. In the immune system, CRTAM is strictly expressed on activated NK cells and activated CD8-positive T cells. By binding its ligand Nectin-like molecule 2 (Necl2), CRTAM plays an important role in mediating cell adhesion and migration.