Clone 113-16 (See other available formats) Regulatory Status RUO Other Names CD27 ligand, CD27L, Ki-24 antigen, Tumor necrosis factor ligand superfamily, member 7 (TNFSF7) Isotype Mouse IgG1, κ Antigen Details Structure Type II transmembrane glycoprotein, member of the tumor necrosis factor superfamily, 50 kD Distribution Activated T cells and B cells, activated NK cells, activated plasmacytoid dendritic cells, some B cell lymphomas Function Role in T cell proliferation, generation of cytolytic and memory T cells, B cell proliferation and differentiation Ligand/Receptor CD27 Cell Type B cells, Dendritic cells, NK cells, T cells Biology Area Costimulatory Molecules, Immunology Molecular Family CD Molecules Antigen References 1. Bowman MR, et al. 1994. J. Immunol. 152:1756. 2. Shaw J, et al. 2010. Blood 115:3051. 3. Keller AM, et al. 2009. Blood 113:5167. Gene ID 970 CD70, also known as CD27L, is a 50 kD type II transmembrane glycoprotein and member of the tumor necrosis factor superfamily. CD70 is expressed on activated T, B and NK cells, activated plasmacytoid dendritic cells (pDCs), and chronic B cell lymphocytic leukemia and large B cell lymphomas. CD70 costimulates T cell proliferation and differentiation. It plays a role in the pDC-induced B cell differentiation. The ligand of CD70 is CD27.