Clone 11A8 (See other available formats) Regulatory Status RUO Other Names DNAM-1, PTA1, TLiSA1 Isotype Mouse IgG1, κ Antigen Details Structure Ig domain containing adhesion molecule Distribution Peripheral blood T cells, NK cells, monocytes/macrophages, platelets and megakaryocytes and a subset of B cells Function Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell Interaction Interacts with LFA-1. Ligand/Receptor PVR (CD155) and Nectin-2 (CD112) Cell Type B cells, Macrophages, Megakaryocytes, Monocytes, NK cells, Platelets, T cells Biology Area Immunology Molecular Family CD Molecules Antigen References 1. Shibuya A et al. 1996. Immunity 4:573. 2. Tahara-Hanaoka S et al. 2004. Int. Immunol. 16:533. 3. Pende D et al. 2005. Mol. Immunol. 42:463. Gene ID 10666 DNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells, NK cells, monocytes/macrophages, platelets and megakaryocytes and a subset of B cells and a member of the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-set. The ligands for CD226 are the poliovirus receptor (CD155) and its family member nectin-2 (CD112), which are broadly expressed on epithelial, endothelial and neuronal cells. CD226 is physically associated with LFA-1 in NK cells and activated T cells, and involved in LFA-1-mediated signaling.