Clone 11B11 (See other available formats) Regulatory Status RUO Other Names Interleukin-4, Ia inducing factor (IaIF), B cell stimulating factor-1 (BSF-1), Hodgkin's cell growth factor (HCGF), Mast cell growth factor-2 (MCGF-2), Macrophage fusion factor (MFF), T cell growth factor-2 (TCGF-2) Isotype Rat IgG1, κ Antigen Details Structure Cytokine; 15-19 kD (Mammalian) Bioactivity Differentiation of naïve CD4+ T cells to the TH2 type, proliferation/differentiation of activated B cells, expression of class II MHC antigens, and of low affinity IgE receptors in resting B cells Cell Sources Mast cells, T cells, bone marrow stromal cells Cell Targets B cells, T cells, monocytes, endothelial cells, fibroblasts Receptors Heterodimer IL-4Rα (CD124); γ-subunit (CD132) in common with IL-2R, IL-7R, IL-13R, IL-15R Cell Type Tregs Biology Area Immunology Molecular Family Cytokines/Chemokines Antigen References 1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego. 2. Boulay J, et al. 1992. Curr. Opin. Immunol. 4:294. 3. Dullens H, et al. 1991. In vivo 5:567. 4. Paul W. 1991. Blood 77:1859. Regulation Upregulated by IL-2, platelet activating factor; downregulated by TGF-β Gene ID 16189 IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development.