Clone 11D5C9 (See other available formats) Regulatory Status RUO Other Names KLRK1, NKR2 Isotype Mouse IgG1, κ Antigen Details Structure A lectin-like type II transmembrane protein Distribution NK cells and a subset of T lymphocytes Function A stimulatory receptor to activate NK cells by association with DAP10 or DAP12 adaptor Ligand/Receptor RAE1L and PRLT Cell Type NK cells, NKT cells, T cells Biology Area Adaptive Immunity, Immunology Molecular Family CD Molecules, Immune Checkpoint Receptors, Innate Immune Signaling Antigen References Obara H, et al. 2005. Am. J. Transplant. 5:2094-103. Raulet DH. 2003. Nat. Rev. Immunol. 3:781-790. Sun Z, et al. 2009. Hepatology. 49:587-597. Dissen E, et al. 1996. J. Exp. Med.183:2197-2207. Løvik G, et al. 1995. J. Immunol. Methods. 179:59-69. Ming Z, et al. 2010. Eur. J. Immunol. 40:1748-1757. Gene ID 24934 NKG2D is a lectin-like type II transmembrane protein also known as CD314. It is expressed on NK cells and a subset of T lymphocytes. NKG2D serves as a stimulatory receptor to activate NK cells via the non-covalently associated DAP10 or DAP12 adaptor. Rat NKG2D has been reported to induce the synthesis of IFN gamma and induce cytotoxicity in response to rat RAE1L and PRLT, RAE family members in rat. NKG2D is also involved in liver allograft rejection.