Clone 11C3.1 (See other available formats) Regulatory Status RUO Other Names Gp34, OX40L, CD134L, CD252, TNFSF4 Isotype Mouse IgG1, κ Antigen Details Structure NGF/TNF superfamily, 35 kD Distribution Activated B cells, activated endothelial cells, mature dendritic cells, airway smooth muscle cells Function B-cell/T-cell interaction, costimulation Ligand/Receptor OX40 (CD134) Cell Type B cells, Dendritic cells, Endothelial cells Biology Area Costimulatory Molecules, Immunology Molecular Family CD Molecules, Immune Checkpoint Receptors Antigen References 1. Imura A, et al. 1996. J. Exp. Med. 183:2185. 2. Ohshima Y, et al. 1997. J. Immunol. 159:3838. 3. Ito T, et al. 2005. J. Exp.Med. 202:1213. 4. Ito T, et al. 2006. Proc. Natl. Acad.Sci. USA. 103:13138. Gene ID 7292 OX40 ligand (OX40L) is a 35 kD type II transmembrane protein which belongs to TNF superfamily, also known as gp34, CD252, CD134L or TNFSF4. The OX40 ligand is expressed on activated B cells, activated endothelial cells, mature dendritic cells, activated CTLs, activated mast cells, and airway smooth muscle cells. OX40 ligand interacts with OX40 antigen (CD134) expressed predominantly on activated T cells to regulate T cell proliferation and differentiation, and to enhance immunoglobulin secretion by activated B cells.