| 别名 |
c fgr, c fgr protooncogene, c src 2 proto oncogene, c src2, Fgr, FGR_HUMAN, FLJ43153, Gardner Rasheed feline sarcoma viral (v fgr), Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, MGC75096, p55 c fgr protein, P55 FGR, P55-FGR, p55c fgr, p58-Fgr, p58c fgr, p58c-Fgr, Proto oncogene c Fgr, Proto oncogene tyrosine protein kinase FGR, Proto-oncogene c-Fgr, SRC 2, SRC2, Tyrosine protein kinase Fgr, Tyrosine-protein kinase Fgr |
| 背景资料 |
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
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