This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
Application
Immunology research
Derived from
E.coli
Purification
NI-NTA affinity purification
Formulation
Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0.
Shipping
The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
Storage
Reconstituted protein solution can be stored at 4-7°C for 2-3 months, stable at < -20°C for 1-2 years.
Reconstitution
Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity
Purity≥85% as determined by reducing SDS-PAGE.
Bioactive
Not tested.
Tag information
With a 6His tag at the N-terminus.
单位
支
规格
10ug 50ug 100ug 1mg
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
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