The protein encoded by this gene is a member of the Ser/Thr protein kinase family.This protein is highly similar to the gene products of S.cerevisiae cdc28 and S.pombe cdc2.It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression.The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a).This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb).Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers.
Application
Immunology research
Derived from
E.coli
Purification
NI-NTA affinity purification
Formulation
Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0.
Shipping
The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
Storage
Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years.
Reconstitution
Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity
Purity≥85% as determined by reducing SDS-PAGE.
Bioactive
Not tested.
Tag information
With a 6His tag at the N-terminus.
单位
支
规格
10ug 50ug 100ug 1mg
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
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