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| CatalogNo: | A21873 |
| Brand: | ABclonal |
| ProductName: | [KD Validated] Bcl-2 Rabbit mAb |
| Gene Symbol: | BCL2 |
| Alias: | Bcl-2; PPP1R50 |
| GeneId: | 596 |
| Swiss-Prot: | P10415 |
| Routing: | Synthetic peptide |
| Species: | Human |
| ProteinWeight: | 26kDa |
| ObservedMW: | 26kDa |
| Source: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bcl-2 (P10415). |
| AntigenSeq: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQA |
| CrossReactivity: | Human |
| Application: | WB, IHC-P, IP, ELISA |
| RecommandDilution: | WB,1:1000 - 1:4000|IHC-P,1:50 - 1:200|IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells|ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage: | Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
| PositiveSamples: | 293T, |
| CelluarLocation: | Endoplasmic reticulum membrane,Mitochondrion outer membrane,Nucleus membrane,Single-pass membrane protein. |
| ResearchArea: | Protein phosphorylation,Cancer,Tumor biomarkers,Invasion and Metastasis,Signal Transduction,PI3K-Akt Signaling Pathway,Cell Biology Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Autophagy,Death Receptor Signaling Pathway,Endocrine Metabolism,Mitochondrial metabolism,Mitochondrial markers,Immunology Inflammation,Neuroscience,Neurodegenerative Diseases,Stem Cells. |
| RRID: | |
| Background: | This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. |
